If you've dreamed of living or working in one of Philadelphia's most iconic and walkable neighborhoods, 148 Vine Street presents a rare Old City opportunity with exceptional live/work and investment potential. This mixed-use property offers over 2,200 square feet of flexible space with two separate entrances, allowing for a wide range of uses. The open, sunlit first-floor commercial storefront is well suited for a boutique, gallery, creative studio, or client-facing office. The space includes a convenient powder room, access to a spacious basement, and a large walk-in refrigerator from its former use as a floral shop. A separate residential entrance leads to a three-story, four-bedroom home above. The second level features a welcoming dining area, a cozy living room with fireplace, inlaid hardwood floors, and a well-equipped kitchen. The third and fourth floors offer generous living space and classic Old City charm, with abundant natural light, a soaking tub, and a dormered upper level. Whether positioned as an owner-occupied live/work property or reimagined as a long-term investment, 148 Vine Street offers flexibility, strong visibility, and enduring demand in one of Philadelphia's most established commercial and residential markets.